BESOIN D’AIDE POUR ANALYSER ET INTERPRÉTER VOS DONNÉES ?
AltraBio est une société de recherche contractuelle spécialisée dans l’analyse de données biologiques et médicales grâce à l’utilisation de méthodes statistiques et d’intelligence artificielle.
Elle est reconnue mondialement comme un partenaire de confiance pour les projets de recherche et développement menés par de grandes entreprises et des hôpitaux universitaires de premier plan évoluant dans divers secteurs tels que les produits pharmaceutiques, les dispositifs médicaux, le diagnostic et les dermato-cosmétiques.
COMMENT TRAVAILLER ENSEMBLE?
Partenariat
Développement d’outils informatiques pour l’analyse de données au sein de consortiums régionaux / nationaux / internationaux.
Exemples de projets réalisés ou en cours:
Sous-traitance
Analyse de données pour des entreprises ou des instituts hospitalo-universitaires.
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Des centaines de projets réalisés
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Des clients réguliers incluant les plus grandes pharmas et les leaders de la cosmétique
FINANCEMENTS
NOUVELLES
mai 2024
18e WRIB
🔬 Nous sommes ravis d'annoncer notre participation au 18e [...]
avril 2024
CYTO 2024
🔬 Nous sommes ravis d'annoncer notre participation au congrès [...]
janvier 2024
Colloque I3M
Nous sommes ravis d'annoncer notre présence au prochain colloque [...]
novembre 2023
Immunotherapies & Innovations for Infectious Diseases
AltraBio est ravi d'annoncer sa présence au prochain I4ID Congress [...]
DERNIERES PUBLICATIONS
2023
Cognasse, Fabrice; Nguyen, Kim Anh; Heestermans, Marco; Bernard, Simon De; Nourikyan, Julien; Duchez, Anne-Claire; Avril, Stéphane; Garraud, Olivier; Hamzeh-Cognasse, Hind
P-CB-16 | Mathematical Models Can Predict Human Platelet Activity and Protein Expressions in Response to Various Stimulations Article de journal
Dans: Transfusion, vol. 63, iss. S5, p. 156A-156A, 2023.
@article{nokey,
title = {P-CB-16 | Mathematical Models Can Predict Human Platelet Activity and Protein Expressions in Response to Various Stimulations},
author = {Fabrice Cognasse and Kim Anh Nguyen and Marco Heestermans and Simon De Bernard and Julien Nourikyan and Anne-Claire Duchez and Stéphane Avril and Olivier Garraud and Hind Hamzeh-Cognasse},
doi = {10.1111/trf.199_17554},
year = {2023},
date = {2023-10-12},
urldate = {2023-10-12},
journal = {Transfusion},
volume = {63},
issue = {S5},
pages = {156A-156A},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Roux, Natacha; Miura, Saori; Dussenne, Mélanie; Tara, Yuki; Lee, Shu-Hua; de Bernard, Simon; Reynaud, Mathieu; Salis, Pauline; Barua, Agneesh; Boulahtouf, Abdelhay; Balaguer, Patrick; Gauthier, Karine; Lecchini, David; Gibert, Yann; Besseau, Laurence; Laudet, Vincent
The multi-level regulation of clownfish metamorphosis by thyroid hormones Article de journal
Dans: Cell Rep, vol. 42, no. 7, p. 112661, 2023, ISSN: 2211-1247.
@article{pmid37347665,
title = {The multi-level regulation of clownfish metamorphosis by thyroid hormones},
author = {Natacha Roux and Saori Miura and Mélanie Dussenne and Yuki Tara and Shu-Hua Lee and Simon de Bernard and Mathieu Reynaud and Pauline Salis and Agneesh Barua and Abdelhay Boulahtouf and Patrick Balaguer and Karine Gauthier and David Lecchini and Yann Gibert and Laurence Besseau and Vincent Laudet},
doi = {10.1016/j.celrep.2023.112661},
issn = {2211-1247},
year = {2023},
date = {2023-06-01},
urldate = {2023-06-01},
journal = {Cell Rep},
volume = {42},
number = {7},
pages = {112661},
abstract = {Most marine organisms have a biphasic life cycle during which pelagic larvae transform into radically different juveniles. In vertebrates, the role of thyroid hormones (THs) in triggering this transition is well known, but how the morphological and physiological changes are integrated in a coherent way with the ecological transition remains poorly explored. To gain insight into this question, we performed an integrated analysis of metamorphosis of a marine teleost, the false clownfish (Amphiprion ocellaris). We show how THs coordinate a change in color vision as well as a major metabolic shift in energy production, highlighting how it orchestrates this transformation. By manipulating the activity of liver X regulator (LXR), a major regulator of metabolism, we also identify a tight link between metabolic changes and metamorphosis progression. Strikingly, we observed that these regulations are at play in the wild, explaining how hormones coordinate energy needs with available resources during the life cycle.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Boussuges, Alain; Chaumet, Guillaume; Boussuges, Martin; Menard, Amelie; Delliaux, Stephane; Brégeon, Fabienne
Ultrasound assessment of the respiratory system using diaphragm motion-volume indices Article de journal
Dans: Front Med (Lausanne), vol. 10, p. 1190891, 2023, ISSN: 2296-858X.
@article{pmid37275363,
title = {Ultrasound assessment of the respiratory system using diaphragm motion-volume indices},
author = {Alain Boussuges and Guillaume Chaumet and Martin Boussuges and Amelie Menard and Stephane Delliaux and Fabienne Brégeon},
doi = {10.3389/fmed.2023.1190891},
issn = {2296-858X},
year = {2023},
date = {2023-05-19},
urldate = {2023-05-19},
journal = {Front Med (Lausanne)},
volume = {10},
pages = {1190891},
abstract = {BACKGROUND: Although previous studies have determined limit values of normality for diaphragm excursion and thickening, it would be beneficial to determine the normal diaphragm motion-to-inspired volume ratio that integrates the activity of the diaphragm and the quality of the respiratory system.
METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.
RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.
CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.
RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.
CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.