Analyse de données médicales

Des Analyses Pertinentes

AltraBio propose son expertise en statistiques pour soutenir vos projets de recherche clinique de la conception à la publication.

Nos statisticiens possèdent une vaste expérience dans l’analyse de données médicales couvrant différents domaines thérapeutiques, notamment (mais sans s’y limiter) la neuropsychiatrie, les neurosciences, la pneumologie, l’immunologie, la dermatologie, la cardiologie et la rhumatologie.

Nous adaptons nos solutions aux besoins spécifiques de nos clients : laboratoires pharmaceutiques en santé humaine ou vétérinaire, fabricants de dispositifs médicaux, biotechs, industries de la cosmétique et de la nutrition, et laboratoires académiques, depuis les phases de développement jusqu’au suivi clinique post-commercialisation.

Conception de l’étude

Calcul de la taille d’échantillon, du nombre d’expériences…
Rédaction du synopsis
Définition de la méthodologie d’analyse
Elaboration du plan d’analyse statistique

Collecte des données

Aide à la rédaction le plan du management des données
Choix de l’eCRF

Traitement des données

Requêtage/Extraction des données
Mise en forme selon les standards d’analyse (CDISC,…)
Prise en compte des données avec des corrections/nettoyage des données (points atypiques, données manquantes…)

Analyse et valorisation des données

Méthodes descriptives, analyses comparatives…
Construction de modèles explicatifs, prédictifs…
Restitution de rapports statistiques classiques ou dynamiques sur le web, d’algorithmes de traitement
Réalisation d’abstract, posters, articles de recherche

Nos dernières publications en analyse de données médicales

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2023

Cognasse, Fabrice; Nguyen, Kim Anh; Heestermans, Marco; Arthaud, Charles-Antoine; Eyraud, Marie-Ange; Prier, Amélie; Bernard, Simon De; Nourikyan, Julien; Duchez, Anne-Claire; Avril, Stéphane; Garraud, Olivier; Hamzeh-Cognasse, Hind

P-228 Les modèles mathématiques peuvent prédire l'activité des plaquettes humaines et les expressions protéiques en réponse à diverses stimulations Article de journal

Dans: Transfusion Clinique et Biologique, vol. 30, iss. S1, p. S147, 2023.

Liens | BibTeX

Cognasse, Fabrice; Nguyen, Kim Anh; Heestermans, Marco; Bernard, Simon De; Nourikyan, Julien; Duchez, Anne-Claire; Avril, Stéphane; Garraud, Olivier; Hamzeh-Cognasse, Hind

P-CB-16 | Mathematical Models Can Predict Human Platelet Activity and Protein Expressions in Response to Various Stimulations Article de journal

Dans: Transfusion, vol. 63, iss. S5, p. 156A-156A, 2023.

Liens | BibTeX

Boussuges, Alain; Chaumet, Guillaume; Boussuges, Martin; Menard, Amelie; Delliaux, Stephane; Brégeon, Fabienne

Ultrasound assessment of the respiratory system using diaphragm motion-volume indices Article de journal

Dans: Front Med (Lausanne), vol. 10, p. 1190891, 2023, ISSN: 2296-858X.

Résumé | Liens | BibTeX

@article{pmid37275363,

title = {Ultrasound assessment of the respiratory system using diaphragm motion-volume indices},

author = {Alain Boussuges and Guillaume Chaumet and Martin Boussuges and Amelie Menard and Stephane Delliaux and Fabienne Brégeon},

doi = {10.3389/fmed.2023.1190891},

issn = {2296-858X},

year  = {2023},

date = {2023-05-19},

urldate = {2023-05-19},

journal = {Front Med (Lausanne)},

volume = {10},

pages = {1190891},

abstract = {BACKGROUND: Although previous studies have determined limit values of normality for diaphragm excursion and thickening, it would be beneficial to determine the normal diaphragm motion-to-inspired volume ratio that integrates the activity of the diaphragm and the quality of the respiratory system.



METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.



RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.



CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

Fermer

BACKGROUND: Although previous studies have determined limit values of normality for diaphragm excursion and thickening, it would be beneficial to determine the normal diaphragm motion-to-inspired volume ratio that integrates the activity of the diaphragm and the quality of the respiratory system.

METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.

RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.

CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.

Fermer

14 Entrées « ‹ 1 de 5 › »