Medical Data Analysis

@article{nokey,

title = {P-CB-16 | Mathematical Models Can Predict Human Platelet Activity and Protein Expressions in Response to Various Stimulations},

author = {Fabrice Cognasse and Kim Anh Nguyen and Marco Heestermans and Simon De Bernard and Julien Nourikyan and Anne-Claire Duchez and Stéphane Avril and Olivier Garraud and Hind Hamzeh-Cognasse},

doi = {10.1111/trf.199_17554},

year  = {2023},

date = {2023-10-12},

urldate = {2023-10-12},

journal = {Transfusion},

volume = {63},

issue = {S5},

pages = {156A-156A},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37275363,

title = {Ultrasound assessment of the respiratory system using diaphragm motion-volume indices},

author = {Alain Boussuges and Guillaume Chaumet and Martin Boussuges and Amelie Menard and Stephane Delliaux and Fabienne Brégeon},

doi = {10.3389/fmed.2023.1190891},

issn = {2296-858X},

year  = {2023},

date = {2023-05-19},

urldate = {2023-05-19},

journal = {Front Med (Lausanne)},

volume = {10},

pages = {1190891},

abstract = {BACKGROUND: Although previous studies have determined limit values of normality for diaphragm excursion and thickening, it would be beneficial to determine the normal diaphragm motion-to-inspired volume ratio that integrates the activity of the diaphragm and the quality of the respiratory system.



METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.



RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.



CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36410115,

title = {Comprehensive morphometric assessment of deltoid muscle development in children: A cross-sectional study},

author = {Teresinha Evangelista and Malick Kandji and Emmanuelle Lacene and Anaïs Chanut and Mai Thao Bui and Rudy Marty and Laurent Buffat and Kenneth Knoblauch and Brian B Rudkin and Norma Beatriz Romero},

doi = {10.1016/j.ebiom.2022.104367},

issn = {2352-3964},

year  = {2022},

date = {2022-12-01},

urldate = {2022-12-01},

journal = {EBioMedicine},

volume = {86},

pages = {104367},

abstract = {BACKGROUND: Normative values for different morphometric parameters of muscle fibres during paediatric development, i.e. from 0 to 18 years, are currently unavailable. They would be of major importance to accurately evaluate pathological changes and could be used as reference biomarkers for evaluating treatment response in clinical trials, or physiological adjustments in sports or ageing.



METHODS: Data were derived from 482 images with a total of 33 094 fibres from 10 μm cross-sections of snap-frozen muscle from 83 deltoid muscle biopsies from patients, 0-18 years, without neuromuscular pathology stained with ATPase 9.4. Data was acquired and analysed with patented image analysis algorithms from "CARPACCIO.cloud". Several parameters were extracted or calculated, including cross-sectional area (CSA), fibre type, circularity, as well as the Minimum diameter of Feret (MinFeret).



FINDINGS: This study illustrates changes in quantitative parameters for muscle morphology over the course of paediatric development and the pivotal changes occurring around puberty. Only fibre size parameters (MinFeret, CSA) are dependent on gender, and only after puberty. All other parameters vary in a similar manner for females and males. The proportion of type 1 fibres is essentially constant from birth to age 10, decreasing to ≈40% by age 18. Circularity decreases with age, to plateau after age 10 for both fibre types.



INTERPRETATION: Normative values and reference charts for muscle fibre types in this age range have been generated to allow comparison of data from patients in pathology laboratories working on neuromuscular diseases.



FUNDING: BPI FRANCE, PULSALYS, Association de l'Institut de Myologie, French National Research Agency (ANR), LABEX CORTEX of Université de Lyon.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}