@article{pmid28435843,

title = {MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis},

author = {Yasmina Bauer and Eric S White and Simon de Bernard and Peter Cornelisse and Isabelle Leconte and Adele Morganti and Sebastien Roux and Oliver Nayler},

doi = {10.1183/23120541.00074-2016},

issn = {2312-0541},

year  = {2017},

date = {2017-01-01},

urldate = {2017-01-01},

journal = {ERJ Open Res},

volume = {3},

number = {1},

abstract = {Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis, which is characterised by destruction of normal lung architecture and excessive deposition of lung extracellular matrix. The heterogeneity of disease progression in patients with IPF poses significant obstacles to patient care and prevents efficient development of novel therapeutic interventions. Blood biomarkers, reflecting pathobiological processes in the lung, could provide objective evidence of the underlying disease. Longitudinally collected serum samples from the Bosentan Use in Interstitial Lung Disease (BUILD)-3 trial were used to measure four biomarkers (metalloproteinase-7 (MMP-7), Fas death receptor ligand, osteopontin and procollagen type I C-peptide), to assess their potential prognostic capabilities and to follow changes during disease progression in patients with IPF. In baseline BUILD-3 samples, only MMP-7 showed clearly elevated protein levels compared with samples from healthy controls, and further investigations demonstrated that MMP-7 levels also increased over time. Baseline levels of MMP-7 were able to predict patients who had higher risk of worsening and, notably, baseline levels of MMP-7 could predict changes in FVC as early as month 4. MMP-7 shows potential to be a reliable predictor of lung function decline and disease progression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Blanc2016-di,

title = {Mature IgM-expressing plasma cells sense antigen and develop  competence for cytokine production upon antigenic challenge},

author = {Pascal Blanc and Ludovic Moro-Sibilot and Lucas Barthly and Ferdinand Jagot and Sébastien This and Simon Bernard and Laurent Buffat and Sébastien Dussurgey and Renaud Colisson and Elias Hobeika and Thierry Fest and Morgan Taillardet and Olivier Thaunat and Antoine Sicard and Paul Mondi`ere and Laurent Genestier and Stephen L Nutt and Thierry Defrance},

doi = {10.1038/ncomms13600},

year  = {2016},

date = {2016-12-01},

urldate = {2016-12-01},

journal = {Nat. Commun.},

volume = {7},

pages = {13600},

abstract = {Dogma holds that plasma cells, as opposed to B cells, cannot bind 

 antigen because they have switched from expression of 

 membrane-bound immunoglobulins (Ig) that constitute the B-cell 

 receptor (BCR) to production of the secreted form of 

 immunoglobulins. Here we compare the phenotypical and functional 

 attributes of plasma cells generated by the T-cell-dependent and 

 T-cell-independent forms of the hapten NP. We show that the 

 nature of the secreted Ig isotype, rather than the chemical 

 structure of the immunizing antigen, defines two functionally 

 distinct populations of plasma cells. Fully mature IgM-expressing 

 plasma cells resident in the bone marrow retain expression of a 

 functional BCR, whereas their IgG+ counterparts do not. Antigen 

 boost modifies the gene expression profile of IgM+ plasma cells 

 and initiates a cytokine production program, characterized by 

 upregulation of CCL5 and IL-10. Our results demonstrate that 

 IgM-expressing plasma cells can sense antigen and acquire 

 competence for cytokine production upon antigenic challenge.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid27924814,

title = {Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge},

author = {Pascal Blanc and Ludovic Moro-Sibilot and Lucas Barthly and Ferdinand Jagot and Sébastien This and Simon de Bernard and Laurent Buffat and Sébastien Dussurgey and Renaud Colisson and Elias Hobeika and Thierry Fest and Morgan Taillardet and Olivier Thaunat and Antoine Sicard and Paul Mondière and Laurent Genestier and Stephen L Nutt and Thierry Defrance},

doi = {10.1038/ncomms13600},

issn = {2041-1723},

year  = {2016},

date = {2016-12-01},

urldate = {2016-12-01},

journal = {Nat Commun},

volume = {7},

pages = {13600},

abstract = {Dogma holds that plasma cells, as opposed to B cells, cannot bind antigen because they have switched from expression of membrane-bound immunoglobulins (Ig) that constitute the B-cell receptor (BCR) to production of the secreted form of immunoglobulins. Here we compare the phenotypical and functional attributes of plasma cells generated by the T-cell-dependent and T-cell-independent forms of the hapten NP. We show that the nature of the secreted Ig isotype, rather than the chemical structure of the immunizing antigen, defines two functionally distinct populations of plasma cells. Fully mature IgM-expressing plasma cells resident in the bone marrow retain expression of a functional BCR, whereas their IgG counterparts do not. Antigen boost modifies the gene expression profile of IgM plasma cells and initiates a cytokine production program, characterized by upregulation of CCL5 and IL-10. Our results demonstrate that IgM-expressing plasma cells can sense antigen and acquire competence for cytokine production upon antigenic challenge.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}