@article{pmid38015712,

title = {Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes},

author = {Taku Nedachi and Christelle Bonod and Julie Rorteau and Wafae Chinoune and Yuri Ishiuchi and Sandrine Hughes and Benjamin Gillet and Nicolas Bechetoille and Dominique Sigaudo-Roussel and Jérôme Lamartine},

doi = {10.18632/aging.205245},

issn = {1945-4589},

year  = {2023},

date = {2023-11-01},

urldate = {2023-11-01},

journal = {Aging (Albany NY)},

volume = {15},

number = {22},

pages = {12702--12722},

abstract = {The disturbance of intercellular communication is one of the hallmarks of aging. The goal of this study is to clarify the impact of chronological aging on extracellular vesicles (EVs), a key mode of communication in mammalian tissues. We focused on epidermal keratinocytes, the main cells of the outer protective layer of the skin which is strongly impaired in the skin of elderly. EVs were purified from conditioned medium of primary keratinocytes isolated from infant or aged adult skin. A significant increase of the relative number of EVs released from aged keratinocytes was observed whereas their size distribution was not modified. By small RNA sequencing, we described a specific microRNA (miRNA) signature of aged EVs with an increase abundance of miR-30a, a key regulator of barrier function in human epidermis. EVs from aged keratinocytes were found to be able to reduce the proliferation of young keratinocytes, to impact their organogenesis properties in a reconstructed epidermis model and to slow down the early steps of skin wound healing in mice, three features observed in aged epidermis. This work reveals that intercellular communication mediated by EVs is modulated during aging process in keratinocytes and might be involved in the functional defects observed in aged skin.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {P-CB-16 | Mathematical Models Can Predict Human Platelet Activity and Protein Expressions in Response to Various Stimulations},

author = {Fabrice Cognasse and Kim Anh Nguyen and Marco Heestermans and Simon De Bernard and Julien Nourikyan and Anne-Claire Duchez and Stéphane Avril and Olivier Garraud and Hind Hamzeh-Cognasse},

doi = {10.1111/trf.199_17554},

year  = {2023},

date = {2023-10-12},

urldate = {2023-10-12},

journal = {Transfusion},

volume = {63},

issue = {S5},

pages = {156A-156A},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37347665,

title = {The multi-level regulation of clownfish metamorphosis by thyroid hormones},

author = {Natacha Roux and Saori Miura and Mélanie Dussenne and Yuki Tara and Shu-Hua Lee and Simon de Bernard and Mathieu Reynaud and Pauline Salis and Agneesh Barua and Abdelhay Boulahtouf and Patrick Balaguer and Karine Gauthier and David Lecchini and Yann Gibert and Laurence Besseau and Vincent Laudet},

doi = {10.1016/j.celrep.2023.112661},

issn = {2211-1247},

year  = {2023},

date = {2023-06-01},

urldate = {2023-06-01},

journal = {Cell Rep},

volume = {42},

number = {7},

pages = {112661},

abstract = {Most marine organisms have a biphasic life cycle during which pelagic larvae transform into radically different juveniles. In vertebrates, the role of thyroid hormones (THs) in triggering this transition is well known, but how the morphological and physiological changes are integrated in a coherent way with the ecological transition remains poorly explored. To gain insight into this question, we performed an integrated analysis of metamorphosis of a marine teleost, the false clownfish (Amphiprion ocellaris). We show how THs coordinate a change in color vision as well as a major metabolic shift in energy production, highlighting how it orchestrates this transformation. By manipulating the activity of liver X regulator (LXR), a major regulator of metabolism, we also identify a tight link between metabolic changes and metamorphosis progression. Strikingly, we observed that these regulations are at play in the wild, explaining how hormones coordinate energy needs with available resources during the life cycle.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}