Need help analysing and interpreting your data?
AltraBio is a contract research company expert in the analysis of biological and medical data through the use of statistical methods and artificial intelligence.
AltraBio is trusted worldwide as a partner for research and development projects by leading companies and university hospitals operating in various sectors including pharmaceuticals, medical devices, diagnostics, and dermato-cosmetics.
How can we work together?
Partnership
Development of computational tools for data analysis in regional/national/international consortia.
Examples of current and completed projects:
Subcontracting
Data analysis for companies and university hospitals.
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Hundreds of completed projects
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Regular customers including top 10 pharmas and leaders in cosmetics
Funding





NEWS
March 2023
Best Biological & Medical Data Analysis Research Company 2023 – Western Europe
We are proud to have been awarded the title [...]
January 2023
XXXI Cosmet’in Lyon Skin Science Days
AltraBio will be present at the XXXI Cosmet'in Lyon Skin [...]
September 2021
CYTO Virtual Interactive Event
Why waste your time analyzing cytometry data manually when gating [...]
LATEST PUBLICATIONS
2022
Todorov, Helena; Prieux, Margaux; Laubreton, Daphne; Bouvier, Matteo; Wang, Shaoying; de Bernard, Simon; Arpin, Christophe; Cannoodt, Robrecht; Saelens, Wouter; Bonnaffoux, Arnaud; Gandrillon, Olivier; Crauste, Fabien; Saeys, Yvan; Marvel, Jacqueline
CD8 memory precursor cell generation is a continuous process Journal Article
In: iScience, vol. 25, no. 9, pp. 104927, 2022, ISSN: 2589-0042.
@article{pmid36065187,
title = {CD8 memory precursor cell generation is a continuous process},
author = {Helena Todorov and Margaux Prieux and Daphne Laubreton and Matteo Bouvier and Shaoying Wang and Simon de Bernard and Christophe Arpin and Robrecht Cannoodt and Wouter Saelens and Arnaud Bonnaffoux and Olivier Gandrillon and Fabien Crauste and Yvan Saeys and Jacqueline Marvel},
doi = {10.1016/j.isci.2022.104927},
issn = {2589-0042},
year = {2022},
date = {2022-09-01},
urldate = {2022-09-01},
journal = {iScience},
volume = {25},
number = {9},
pages = {104927},
abstract = {In this work, we studied the generation of memory precursor cells following an acute infection by analyzing single-cell RNA-seq data that contained CD8 T cells collected during the postinfection expansion phase. We used different tools to reconstruct the developmental trajectory that CD8 T cells followed after activation. Cells that exhibited a memory precursor signature were identified and positioned on this trajectory. We found that these memory precursors are generated continuously with increasing numbers arising over time. Similarly, expression of genes associated with effector functions was also found to be raised in memory precursors at later time points. The ability of cells to enter quiescence and differentiate into memory cells was confirmed by BrdU pulse-chase experiment . Analysis of cell counts indicates that the vast majority of memory cells are generated at later time points from cells that have extensively divided.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Silic, Linda Ljungberg; Lefevre, Marine-Alexia; Bergendorff, Ola; Bernard, Simon De; Nourikyan, Julien; Buffat, Laurent; Nosbaum, Audrey; Bruze, Magnus; cois Nicolas, Jean-Franc; Svedman, Cecilia; Vocanson, Marc
Gene profiling reveals a contact allergy signature in most positive Amerchol L-101 patch test reactions Journal Article
In: Contact Dermatitis, vol. 87, no. 1, pp. 40–52, 2022.
@article{Silic2022,
title = {Gene profiling reveals a contact allergy signature in most positive Amerchol L-101 patch test reactions},
author = {Linda Ljungberg Silic and Marine-Alexia Lefevre and Ola Bergendorff and Simon De Bernard and Julien Nourikyan and Laurent Buffat and Audrey Nosbaum and Magnus Bruze and Jean-Franc cois Nicolas and Cecilia Svedman and Marc Vocanson},
year = {2022},
date = {2022-07-01},
urldate = {2022-07-01},
journal = {Contact Dermatitis},
volume = {87},
number = {1},
pages = {40--52},
publisher = {Wiley},
abstract = {BACKGROUND: Diagnosis of contact allergy (CA) to Amerchol L-101
(AL-101), a marker for lanolin allergy, is problematic. Positive
patch test reactions are frequently doubtful or weakly positive
and difficult to associate with clinical relevance. OBJECTIVE:
To gain further insight on the allergic or irritant nature of
skin reactions induced by AL-101 patch test. METHODS: We
re-tested in a dose-response fashion, 10 subjects with AL-101 CA
and performed comprehensive transcriptomic analysis (gene
arrays, quantitative real-time polymerase chain reaction
[qRT-PCR]) of samples of their skin reactions. RESULTS: Eight of
the 10 CA subjects reacted positively upon re-test, whereas two
did not react. Most of AL-101 positive patch tests expressed an
allergy signature with strong activation of gene modules
associated with adaptive immunity and downregulation of
cornification pathway genes. In addition, the breadth of gene
modulation correlated with the magnitude of patch test reactions
and the concentration of AL-101 applied. However, we observed
that some of the positive patch test reactions to AL-101
expressed no/few allergy biomarkers, suggesting the induction of
an irritant skin inflammation in these samples. CONCLUSIONS:
This study confirms that AL-101 is an allergen that can cause
both contact allergy and contact irritation. Our results also
highlight that molecular profiling might help to strengthen
clinical diagnosis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
(AL-101), a marker for lanolin allergy, is problematic. Positive
patch test reactions are frequently doubtful or weakly positive
and difficult to associate with clinical relevance. OBJECTIVE:
To gain further insight on the allergic or irritant nature of
skin reactions induced by AL-101 patch test. METHODS: We
re-tested in a dose-response fashion, 10 subjects with AL-101 CA
and performed comprehensive transcriptomic analysis (gene
arrays, quantitative real-time polymerase chain reaction
[qRT-PCR]) of samples of their skin reactions. RESULTS: Eight of
the 10 CA subjects reacted positively upon re-test, whereas two
did not react. Most of AL-101 positive patch tests expressed an
allergy signature with strong activation of gene modules
associated with adaptive immunity and downregulation of
cornification pathway genes. In addition, the breadth of gene
modulation correlated with the magnitude of patch test reactions
and the concentration of AL-101 applied. However, we observed
that some of the positive patch test reactions to AL-101
expressed no/few allergy biomarkers, suggesting the induction of
an irritant skin inflammation in these samples. CONCLUSIONS:
This study confirms that AL-101 is an allergen that can cause
both contact allergy and contact irritation. Our results also
highlight that molecular profiling might help to strengthen
clinical diagnosis.
Silic, Linda Ljungberg; Lefevre, Marine-Alexia; Bergendorff, Ola; Bernard, Simon De; Nourikyan, Julien; Buffat, Laurent; Nosbaum, Audrey; Bruze, Magnus; Nicolas, Jean-François; Svedman, Cecilia; Vocanson, Marc
Gene profiling reveals a contact allergy signature in most positive Amerchol L-101 patch test reactions Journal Article
In: Contact Dermatitis, vol. 87, no. 1, pp. 40–52, 2022, ISSN: 1600-0536.
@article{pmid35184302,
title = {Gene profiling reveals a contact allergy signature in most positive Amerchol L-101 patch test reactions},
author = {Linda Ljungberg Silic and Marine-Alexia Lefevre and Ola Bergendorff and Simon De Bernard and Julien Nourikyan and Laurent Buffat and Audrey Nosbaum and Magnus Bruze and Jean-François Nicolas and Cecilia Svedman and Marc Vocanson},
doi = {10.1111/cod.14077},
issn = {1600-0536},
year = {2022},
date = {2022-07-01},
urldate = {2022-07-01},
journal = {Contact Dermatitis},
volume = {87},
number = {1},
pages = {40--52},
abstract = {BACKGROUND: Diagnosis of contact allergy (CA) to Amerchol L-101 (AL-101), a marker for lanolin allergy, is problematic. Positive patch test reactions are frequently doubtful or weakly positive and difficult to associate with clinical relevance.
OBJECTIVE: To gain further insight on the allergic or irritant nature of skin reactions induced by AL-101 patch test.
METHODS: We re-tested in a dose-response fashion, 10 subjects with AL-101 CA and performed comprehensive transcriptomic analysis (gene arrays, quantitative real-time polymerase chain reaction [qRT-PCR]) of samples of their skin reactions.
RESULTS: Eight of the 10 CA subjects reacted positively upon re-test, whereas two did not react. Most of AL-101 positive patch tests expressed an allergy signature with strong activation of gene modules associated with adaptive immunity and downregulation of cornification pathway genes. In addition, the breadth of gene modulation correlated with the magnitude of patch test reactions and the concentration of AL-101 applied. However, we observed that some of the positive patch test reactions to AL-101 expressed no/few allergy biomarkers, suggesting the induction of an irritant skin inflammation in these samples.
CONCLUSIONS: This study confirms that AL-101 is an allergen that can cause both contact allergy and contact irritation. Our results also highlight that molecular profiling might help to strengthen clinical diagnosis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: To gain further insight on the allergic or irritant nature of skin reactions induced by AL-101 patch test.
METHODS: We re-tested in a dose-response fashion, 10 subjects with AL-101 CA and performed comprehensive transcriptomic analysis (gene arrays, quantitative real-time polymerase chain reaction [qRT-PCR]) of samples of their skin reactions.
RESULTS: Eight of the 10 CA subjects reacted positively upon re-test, whereas two did not react. Most of AL-101 positive patch tests expressed an allergy signature with strong activation of gene modules associated with adaptive immunity and downregulation of cornification pathway genes. In addition, the breadth of gene modulation correlated with the magnitude of patch test reactions and the concentration of AL-101 applied. However, we observed that some of the positive patch test reactions to AL-101 expressed no/few allergy biomarkers, suggesting the induction of an irritant skin inflammation in these samples.
CONCLUSIONS: This study confirms that AL-101 is an allergen that can cause both contact allergy and contact irritation. Our results also highlight that molecular profiling might help to strengthen clinical diagnosis.