Relevant analyses
AltraBio provides statistical expertise to assist with your clinical research projects from inception to publication.
Our statisticians possess extensive experience in analyzing medical data across various therapeutic areas including (but not limited to) neuropsychiatry, neurosciences, pulmonology, immunology, dermatology, cardiology, and rheumatology.
We tailor our solutions to meet the specific needs of our clients, which include human and veterinary pharmaceutical companies, medical device manufacturers, biotechs, cosmetic and nutritional industries, and academic laboratories. Our services span from the development phases to post-market clinical follow-up.
Study design
- Sample size and power calculation
- Writing of the synopsis
- Definition of the analysis methodology
- Development of the Statistical Analysis Plan
Data collection
- Support for writing the Data Management Plan
- Selection of the eCRF
Data processing
- Data extraction
- Formatting in accordance with the standards (CDISC, …)
- Data correction and cleaning (atypical data, missing data, …)
Data Analysis and valorization
- Descriptive methods, comparative analyses, …
- Construction of explanatory or predictive models, …
- Delivery of statistical reports in the form of a pdf or of a dynamic web page, processing algorithms
- Writing of abstracts, posters, research articles
Our Publications In Medical Data Analysis
2019
Boussuges, Alain; Chaumet, Guillaume; Vallée, Nicolas; Risso, Jean Jacques; Pontier, Jean Michel
High Bubble Grade After Diving: The Role of the Blood Pressure Regimen Journal Article
In: Front Physiol, vol. 10, pp. 749, 2019, ISSN: 1664-042X.
@article{pmid31281261b,
title = {High Bubble Grade After Diving: The Role of the Blood Pressure Regimen},
author = {Alain Boussuges and Guillaume Chaumet and Nicolas Vallée and Jean Jacques Risso and Jean Michel Pontier},
doi = {10.3389/fphys.2019.00749},
issn = {1664-042X},
year = {2019},
date = {2019-01-01},
urldate = {2019-01-01},
journal = {Front Physiol},
volume = {10},
pages = {749},
abstract = { Previous studies have suggested that the circulatory system was involved in the production of circulatory bubbles after diving. This study was designed to research the cardio-vascular function characteristics related to the production of high bubble grades after diving. Thirty trained divers were investigated both at baseline and after a 30-msw SCUBA dive. At baseline, the investigations included blood pressure measurement, echocardiography, and assessment of aerobic fitness using VO peak measurement. Blood samples were taken at rest, to measure the plasma concentration of NOx and endothelin-1. After diving, circulating bubbles were detected in the pulmonary artery by pulsed Doppler at 20-min intervals during the 90 min after surfacing. The global bubble quantity production was estimated by the KISS index. Divers with a high bubble grade (KISS > 7.5) had systolic blood pressure, pulse pressure, weight, and height significantly higher than divers with a low bubble grade. By contrast, total arterial compliance, plasma NOx level, and percentage of predicted value of peak oxygen uptake were significantly lower in divers with a high bubble grade. Cardiac dimensions, left ventricular function, and plasma endothelin-1 concentration were not significantly different between groups. The multivariate analysis identified blood pressure as the main contributor of the quantity of bubble production. The model including pulse pressure, plasma NOx level, and percentage of predicted value of peak oxygen uptake has an explanatory power of 49.22%. The viscoelastic properties of the arterial tree appeared to be an important contributor to the circulating bubble production after a dive.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2018
Gavarry, Olivier; Lentin, Gregory; Pezery, Patrick; Delextrat, Anne; Chaumet, Guillaume; Boussuges, Alain; Piscione, Julien
A Cross-Sectional Study Assessing the Contributions of Body Fat Mass and Fat-Free Mass to Body Mass Index Scores in Male Youth Rugby Players Journal Article
In: Sports Med Open, vol. 4, no. 1, pp. 17, 2018, ISSN: 2199-1170.
@article{pmid29721761,
title = {A Cross-Sectional Study Assessing the Contributions of Body Fat Mass and Fat-Free Mass to Body Mass Index Scores in Male Youth Rugby Players},
author = {Olivier Gavarry and Gregory Lentin and Patrick Pezery and Anne Delextrat and Guillaume Chaumet and Alain Boussuges and Julien Piscione},
doi = {10.1186/s40798-018-0130-7},
issn = {2199-1170},
year = {2018},
date = {2018-05-01},
urldate = {2018-05-01},
journal = {Sports Med Open},
volume = {4},
number = {1},
pages = {17},
abstract = {BACKGROUND: In some sports such as rugby, a large body size is an advantage, and the desire to gain weight can bring young players to become overweight or obese. The aim of this study was to evaluate the prevalence of overweight and obesity and the contribution of body fat mass index (BFMI) and fat-free mass index (FFMI) to body mass index (BMI) changes among young male rugby players (15-a-side rugby).
METHODS: The criteria of the International Obesity Task Force were used to define overweight and obesity from BMI. The method of skinfold thickness was used to assess percentage of body fat (%BF), BFMI, and FFMI. Excess body fat was defined by using BFMI and %BF above the 75th percentile. Data were grouped according to the age categories of the French Rugby Federation (U11, under 11 years; U13, under 13 years; U15, under 15 years) and to BMI status (NW normal-weight versus OW/OB overweight/obese).
RESULTS: Overall, 32.8% of the young players were overweight, and 13.8% were obese. However, 53% of young players classified as obese and overweight by BMI had an excess body fat by using BFMI above the 75th percentile. FFMI increased significantly between U11 and U13 in both groups, without significant change in BMI and BFMI. Both groups had similar significant gains in BMI and FFMI between U13 and U15, while BFMI only increased significantly in OW/OB (+ 18.5%). The strong correlations between BMI and %BF were systematically lower than those between BMI and BFMI. FFMI was strongly or moderately associated with BFMI.
CONCLUSIONS: Chart analysis of BFMI and FFMI could be used to distinguish changes in body composition across age categories in young male rugby players classified as normal-weight, overweight, and obese by BMI.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
METHODS: The criteria of the International Obesity Task Force were used to define overweight and obesity from BMI. The method of skinfold thickness was used to assess percentage of body fat (%BF), BFMI, and FFMI. Excess body fat was defined by using BFMI and %BF above the 75th percentile. Data were grouped according to the age categories of the French Rugby Federation (U11, under 11 years; U13, under 13 years; U15, under 15 years) and to BMI status (NW normal-weight versus OW/OB overweight/obese).
RESULTS: Overall, 32.8% of the young players were overweight, and 13.8% were obese. However, 53% of young players classified as obese and overweight by BMI had an excess body fat by using BFMI above the 75th percentile. FFMI increased significantly between U11 and U13 in both groups, without significant change in BMI and BFMI. Both groups had similar significant gains in BMI and FFMI between U13 and U15, while BFMI only increased significantly in OW/OB (+ 18.5%). The strong correlations between BMI and %BF were systematically lower than those between BMI and BFMI. FFMI was strongly or moderately associated with BFMI.
CONCLUSIONS: Chart analysis of BFMI and FFMI could be used to distinguish changes in body composition across age categories in young male rugby players classified as normal-weight, overweight, and obese by BMI.
2017
Boussuges, A; Ayme, K; Chaumet, G; Albier, E; Borgnetta, M; Gavarry, O
Observational study of potential risk factors of immersion pulmonary edema in healthy divers: exercise intensity is the main contributor Journal Article
In: Sports Med Open, vol. 3, no. 1, pp. 35, 2017, ISSN: 2199-1170.
@article{pmid28975560,
title = {Observational study of potential risk factors of immersion pulmonary edema in healthy divers: exercise intensity is the main contributor},
author = {A Boussuges and K Ayme and G Chaumet and E Albier and M Borgnetta and O Gavarry},
doi = {10.1186/s40798-017-0104-1},
issn = {2199-1170},
year = {2017},
date = {2017-10-01},
urldate = {2017-10-01},
journal = {Sports Med Open},
volume = {3},
number = {1},
pages = {35},
abstract = {BACKGROUND: The risk factors of pulmonary edema induced by diving in healthy subjects are not well known. The aim of the present study was to assess the parameters contributing to the increase in extravascular lung water after diving.
METHODS: This study was carried out in a professional diving institute. All divers participating in the teaching program from June 2012 to June 2014 were included in the study. Extravascular lung water was assessed using the detection of ultrasound lung comets (ULC) by chest ultrasonography. Clinical parameters and dive profiles were recorded using a questionnaire and a dive computer.
RESULTS: One-hundred six divers were investigated after 263 dives. They used an open-circuit umbilical supplying compressed gas diving apparatus in 202 cases and a self-contained underwater breathing apparatus in 61 cases. A generalized linear mixed model analysis was performed which demonstrated that the dive induced a significant increase in ULC score (incidence rate ratio: 3.16). It also identified that the predictive variable of increased extravascular lung water after the dive was the exercise intensity at depth (z = 3.99, p < 0.0001). The other parameters studied such as the water temperature, dive profile, hyperoxic exposure, or anthropometric data were not associated with the increase in extravascular lung water after the dive.
CONCLUSIONS: In this study, the exercise intensity was the main contributor to the increase in extravascular lung water in healthy divers. To improve the prevention of immersion pulmonary edema, the exercise intensity experienced during the dive should thus be adapted to the aerobic fitness level of the divers.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
METHODS: This study was carried out in a professional diving institute. All divers participating in the teaching program from June 2012 to June 2014 were included in the study. Extravascular lung water was assessed using the detection of ultrasound lung comets (ULC) by chest ultrasonography. Clinical parameters and dive profiles were recorded using a questionnaire and a dive computer.
RESULTS: One-hundred six divers were investigated after 263 dives. They used an open-circuit umbilical supplying compressed gas diving apparatus in 202 cases and a self-contained underwater breathing apparatus in 61 cases. A generalized linear mixed model analysis was performed which demonstrated that the dive induced a significant increase in ULC score (incidence rate ratio: 3.16). It also identified that the predictive variable of increased extravascular lung water after the dive was the exercise intensity at depth (z = 3.99, p < 0.0001). The other parameters studied such as the water temperature, dive profile, hyperoxic exposure, or anthropometric data were not associated with the increase in extravascular lung water after the dive.
CONCLUSIONS: In this study, the exercise intensity was the main contributor to the increase in extravascular lung water in healthy divers. To improve the prevention of immersion pulmonary edema, the exercise intensity experienced during the dive should thus be adapted to the aerobic fitness level of the divers.