Medical data analysis

Relevant analyses

AltraBio offers its expertise in statistics to support your clinical research projects from conception to publication.

Our statisticians have extensive experience in the analysis of medical data covering different therapeutic areas including (but not limited to) neuropsychiatry, neurosciences, pulmonology, immunology, dermatology, cardiology and rheumatology.

We adapt our solutions to the specific needs of our clients: human and veterinary pharmaceutical companies, medical device manufacturers, biotechs, cosmetic and nutritional industries and academic laboratories, from the development phases to the “Post Market Clinical Folow up”.

Study design

Sample size and power calculation
Writing of the synopsis
Definition of the analysis methodology
Development of the Statistical Analysis Plan

Data collection

Support for writing the Data Management Plan
Selection of the eCRF

Data processing

Data extraction
Formatting in accordance with the standards (CDISC, …)
Data correction and cleaning (atypical data, missing data, …)

Data Analysis and valorization

Descriptive methods, comparative analyses, …
Construction of explanatory or predictive models, …
Delivery of statistical reports in the form of a pdf or of a dynamic web page, processing algorithms
Writing of abstracts, posters, research articles

Our Publications In Medical Data Analysis

11 entries « ‹ 4 of 4 › »

2018

Gavarry, Olivier; Lentin, Gregory; Pezery, Patrick; Delextrat, Anne; Chaumet, Guillaume; Boussuges, Alain; Piscione, Julien

A Cross-Sectional Study Assessing the Contributions of Body Fat Mass and Fat-Free Mass to Body Mass Index Scores in Male Youth Rugby Players Journal Article

In: Sports Med Open, vol. 4, no. 1, pp. 17, 2018, ISSN: 2199-1170.

Abstract | Links | BibTeX

@article{pmid29721761,

title = {A Cross-Sectional Study Assessing the Contributions of Body Fat Mass and Fat-Free Mass to Body Mass Index Scores in Male Youth Rugby Players},

author = {Olivier Gavarry and Gregory Lentin and Patrick Pezery and Anne Delextrat and Guillaume Chaumet and Alain Boussuges and Julien Piscione},

doi = {10.1186/s40798-018-0130-7},

issn = {2199-1170},

year  = {2018},

date = {2018-05-01},

urldate = {2018-05-01},

journal = {Sports Med Open},

volume = {4},

number = {1},

pages = {17},

abstract = {BACKGROUND: In some sports such as rugby, a large body size is an advantage, and the desire to gain weight can bring young players to become overweight or obese. The aim of this study was to evaluate the prevalence of overweight and obesity and the contribution of body fat mass index (BFMI) and fat-free mass index (FFMI) to body mass index (BMI) changes among young male rugby players (15-a-side rugby).



METHODS: The criteria of the International Obesity Task Force were used to define overweight and obesity from BMI. The method of skinfold thickness was used to assess percentage of body fat (%BF), BFMI, and FFMI. Excess body fat was defined by using BFMI and %BF above the 75th percentile. Data were grouped according to the age categories of the French Rugby Federation (U11, under 11 years; U13, under 13 years; U15, under 15 years) and to BMI status (NW normal-weight versus OW/OB overweight/obese).



RESULTS: Overall, 32.8% of the young players were overweight, and 13.8% were obese. However, 53% of young players classified as obese and overweight by BMI had an excess body fat by using BFMI above the 75th percentile. FFMI increased significantly between U11 and U13 in both groups, without significant change in BMI and BFMI. Both groups had similar significant gains in BMI and FFMI between U13 and U15, while BFMI only increased significantly in OW/OB (+ 18.5%). The strong correlations between BMI and %BF were systematically lower than those between BMI and BFMI. FFMI was strongly or moderately associated with BFMI.



CONCLUSIONS: Chart analysis of BFMI and FFMI could be used to distinguish changes in body composition across age categories in young male rugby players classified as normal-weight, overweight, and obese by BMI.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

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2017

Boussuges, A; Ayme, K; Chaumet, G; Albier, E; Borgnetta, M; Gavarry, O

Observational study of potential risk factors of immersion pulmonary edema in healthy divers: exercise intensity is the main contributor Journal Article

In: Sports Med Open, vol. 3, no. 1, pp. 35, 2017, ISSN: 2199-1170.

Abstract | Links | BibTeX

@article{pmid28975560,

title = {Observational study of potential risk factors of immersion pulmonary edema in healthy divers: exercise intensity is the main contributor},

author = {A Boussuges and K Ayme and G Chaumet and E Albier and M Borgnetta and O Gavarry},

doi = {10.1186/s40798-017-0104-1},

issn = {2199-1170},

year  = {2017},

date = {2017-10-01},

urldate = {2017-10-01},

journal = {Sports Med Open},

volume = {3},

number = {1},

pages = {35},

abstract = {BACKGROUND: The risk factors of pulmonary edema induced by diving in healthy subjects are not well known. The aim of the present study was to assess the parameters contributing to the increase in extravascular lung water after diving.



METHODS: This study was carried out in a professional diving institute. All divers participating in the teaching program from June 2012 to June 2014 were included in the study. Extravascular lung water was assessed using the detection of ultrasound lung comets (ULC) by chest ultrasonography. Clinical parameters and dive profiles were recorded using a questionnaire and a dive computer.



RESULTS: One-hundred six divers were investigated after 263 dives. They used an open-circuit umbilical supplying compressed gas diving apparatus in 202 cases and a self-contained underwater breathing apparatus in 61 cases. A generalized linear mixed model analysis was performed which demonstrated that the dive induced a significant increase in ULC score (incidence rate ratio: 3.16). It also identified that the predictive variable of increased extravascular lung water after the dive was the exercise intensity at depth (z = 3.99, p < 0.0001). The other parameters studied such as the water temperature, dive profile, hyperoxic exposure, or anthropometric data were not associated with the increase in extravascular lung water after the dive.



CONCLUSIONS: In this study, the exercise intensity was the main contributor to the increase in extravascular lung water in healthy divers. To improve the prevention of immersion pulmonary edema, the exercise intensity experienced during the dive should thus be adapted to the aerobic fitness level of the divers.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

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11 entries « ‹ 4 of 4 › »