Medical data analysis

Relevant analyses

AltraBio offers its expertise in statistics to support your clinical research projects from conception to publication.

Our statisticians have extensive experience in the analysis of medical data covering different therapeutic areas including (but not limited to) neuropsychiatry, neurosciences, pulmonology, immunology, dermatology, cardiology and rheumatology.

We adapt our solutions to the specific needs of our clients: human and veterinary pharmaceutical companies, medical device manufacturers, biotechs, cosmetic and nutritional industries and academic laboratories, from the development phases to the “Post Market Clinical Follow up”.

Study design

Sample size and power calculation
Writing of the synopsis
Definition of the analysis methodology
Development of the Statistical Analysis Plan

Data collection

Support for writing the Data Management Plan
Selection of the eCRF

Data processing

Data extraction
Formatting in accordance with the standards (CDISC, …)
Data correction and cleaning (atypical data, missing data, …)

Data Analysis and valorization

Descriptive methods, comparative analyses, …
Construction of explanatory or predictive models, …
Delivery of statistical reports in the form of a pdf or of a dynamic web page, processing algorithms
Writing of abstracts, posters, research articles

Our Publications In Medical Data Analysis

14 entries « ‹ 1 of 5 › »

2023

Cognasse, Fabrice; Nguyen, Kim Anh; Heestermans, Marco; Arthaud, Charles-Antoine; Eyraud, Marie-Ange; Prier, Amélie; Bernard, Simon De; Nourikyan, Julien; Duchez, Anne-Claire; Avril, Stéphane; Garraud, Olivier; Hamzeh-Cognasse, Hind

P-228 Les modèles mathématiques peuvent prédire l'activité des plaquettes humaines et les expressions protéiques en réponse à diverses stimulations Journal Article

In: Transfusion Clinique et Biologique, vol. 30, iss. S1, pp. S147, 2023.

Links | BibTeX

Cognasse, Fabrice; Nguyen, Kim Anh; Heestermans, Marco; Bernard, Simon De; Nourikyan, Julien; Duchez, Anne-Claire; Avril, Stéphane; Garraud, Olivier; Hamzeh-Cognasse, Hind

P-CB-16 | Mathematical Models Can Predict Human Platelet Activity and Protein Expressions in Response to Various Stimulations Journal Article

In: Transfusion, vol. 63, iss. S5, pp. 156A-156A, 2023.

Links | BibTeX

Boussuges, Alain; Chaumet, Guillaume; Boussuges, Martin; Menard, Amelie; Delliaux, Stephane; Brégeon, Fabienne

Ultrasound assessment of the respiratory system using diaphragm motion-volume indices Journal Article

In: Front Med (Lausanne), vol. 10, pp. 1190891, 2023, ISSN: 2296-858X.

Abstract | Links | BibTeX

@article{pmid37275363,

title = {Ultrasound assessment of the respiratory system using diaphragm motion-volume indices},

author = {Alain Boussuges and Guillaume Chaumet and Martin Boussuges and Amelie Menard and Stephane Delliaux and Fabienne Brégeon},

doi = {10.3389/fmed.2023.1190891},

issn = {2296-858X},

year  = {2023},

date = {2023-05-19},

urldate = {2023-05-19},

journal = {Front Med (Lausanne)},

volume = {10},

pages = {1190891},

abstract = {BACKGROUND: Although previous studies have determined limit values of normality for diaphragm excursion and thickening, it would be beneficial to determine the normal diaphragm motion-to-inspired volume ratio that integrates the activity of the diaphragm and the quality of the respiratory system.



METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.



RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.



CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

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BACKGROUND: Although previous studies have determined limit values of normality for diaphragm excursion and thickening, it would be beneficial to determine the normal diaphragm motion-to-inspired volume ratio that integrates the activity of the diaphragm and the quality of the respiratory system.

METHODS: To determine the normal values of selected ultrasound diaphragm motion-volume indices, subjects with normal pulmonary function testing were recruited. Ultrasound examination recorded diaphragm excursion on both sides during quiet breathing and deep inspiration. Diaphragm thickness was also measured. The inspired volumes of the corresponding cycles were systematically recorded using a spirometer. The indices were calculated using the ratio excursion, or percentage of thickening, divided by the corresponding breathing volume. From this corhort, normal values and limit values for normality were determined. These measurements were compared to those performed on the healthy side in patients with hemidiaphragm paralysis because an increase in hemidiaphragm activity has been previously demonstated in such circumstances.

RESULTS: A total of 122 subjects (51 women, 71 men) with normal pulmonary function were included in the study. Statistical analysis revealed that the ratio of excursion, or percentage of thickening, to inspired volume ratio significantly differed between males and females. When the above-mentioned indices using excursion were normalized by body weight, no gender differences were found. The indices differed between normal respiratory function subjects and patients with hemidiaphragm paralysis (27 women, 41 men). On the paralyzed side, the average ratio of the excursion divided by the inspired volume was zero. On the healthy side, the indices using the excursion and the percentage of thickening during quiet breathing or deep inspiration were significantly increased comparedto patients with normal lung function. According to the logistic regression analysis, the most relevant indice appeared to be the ratio of the excursion measured during quiet breathing to the inspired volume.

CONCLUSION: The normal values of the diaphragm motion-volume indices could be useful to estimate the performance of the respiratory system. Proposed indices appear suitable in a context of hyperactivity.

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14 entries « ‹ 1 of 5 › »