Laurent Buffat

Ph.D. in biostatistics and biomathematics (University Paris 7) and M.D. (University Lyon 1), Laurent also possesses a DEA in biomedical science and attended an executive education program in Entrepreneurial Leadership at EM-Lyon, one of the foremost European business schools. Prior to founding AltraBio, Laurent was head of the biostatistics and bioinformatics division and CSO of ValiGen SA, an Euro-American biotechnology company, and IT.Omics, an European bioinformatics company. He is also the founder and CEO of APCure, a pharmaceutical start-up which develops Immunotherapeutic products. 

Publications

Poly-functional and long-lasting anticancer immune response elicited by a safe attenuated Pseudomonas aeruginosa vector for antigens delivery. Chauchet X, Hannani D, Djebali S, Laurin D, Polack B, Marvel J, Buffat L, Toussaint B, Le Gouëllec A. Mol Ther Oncolytics. 2016 Dec; 3:16033.

Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge. Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R, Hobeika E, Fest T, Taillardet M, Thaunat O, Sicard A, Mondière P, Genestier L, Nutt SL, Defrance T. Nat Commun. 2016 Dec; 7:13600.

Immune signatures of protective spleen memory CD8 T cells. Brinza L, Djebali S, Tomkowiak M, Mafille J, Loiseau C, Jouve PE, de Bernard S, Buffat L, Lina B, Ottmann M, Rosa-Calatrava M, Schicklin S, Bonnefoy N, Lauvau G, Grau M, Wencker M, Arpin C, Walzer T, Leverrier Y, Marvel J.  Sci Rep. 2016 Nov; 6:37651.

CD1d-restricted peripheral T cell lymphoma in mice and humans. Bachy E, Urb M, Chandra S, Robinot R, Bricard G, de Bernard S, Traverse-Glehen A, Gazzo S, Blond O, Khurana A, Baseggio L, Heavican T, Ffrench M, Crispatzu G, Mondière P, Schrader A, Taillardet M, Thaunat O, Martin N, Dalle S, Le Garff-Tavernier M, Salles G, Lachuer J, Hermine O, Asnafi V, Roussel M, Lamy T, Herling M, Iqbal J, Buffat L, Marche PN, Gaulard P, Kronenberg M, Defrance T, Genestier L. J Exp Med. 2016 May; 213(5):841-57.

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection. van Helden MJ, Goossens S, Daussy C, Mathieu AL, Faure F, Marçais A, Vandamme N, Farla N, Mayol K, Viel S, Degouve S, Debien E, Seuntjens E, Conidi A, Chaix J, Mangeot P, de Bernard S, Buffat L, Haigh JJ, Huylebroeck D, Lambrecht BN, Berx G, Walzer T. J Exp Med. 2015 Nov; 212(12):2015-25.

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. J Exp Med. 2014 Mar; 211(3):563-77.

Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo. Samarut E, Gaudin C, Hughes S, Gillet B, de Bernard S, Jouve PE, Buffat L, Allot A, Lecompte O, Berekelya L, Rochette-Egly C, Laudet V. Mol Endocrinol. 2014 Feb; 28(2):260-72.

Bacterial vectors for active immunotherapy reach clinical and industrial stages. Le Gouëllec A, Chauchet X, Polack B, Buffat L, Toussaint B. Hum Vaccin Immunother. 2012 Oct; 8(10):1454-8.

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. Shiri-Sverdlov R, Wouters K, van Gorp PJ, Gijbels MJ, Noel B, Buffat L, Staels B, Maeda N, van Bilsen M, Hofker MH. J Hepatol. 2006 Apr; 44(4):732-41.

Integrative analysis of gene expression patterns predicts specific modulations of defined cell functions by estrogen and tamoxifen in MCF7 breast cancer cells. Gadal F, Starzec A, Bozic C, Pillot-Brochet C, Malinge S, Ozanne V, Vicenzi J, Buffat L, Perret G, Iris F, Crepin M. J Mol Endocrinol. 2005 Feb; 34(1):61-75.

Integrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line. Gadal F, Bozic C, Pillot-Brochet C, Malinge S, Wagner S, Le Cam A, Buffat L, Crepin M, Iris F. Nucleic Acids Res. 2003 Oct; 31(19):5789-804.

Endometrial adenocarcinoma treated with combined radiotherapy and surgery: 437 cases. Touboul E, Belkacémi Y, Buffat L, Deniaud-Alexandre E, Lefranc JP, Lhuillier P, Uzan S, Jannet D, Uzan M, Antoine M, Ginesty C, Ganansia V, Jamali M, Milliez J, Blondon J, Schlienger M. Cancer Radiother. 2001 Aug; 5(4):425-44.

Adenocarcinoma of the endometrium treated with combined irradiation and surgery: study of 437 patients. Touboul E, Belkacémi Y, Buffat L, Deniaud-Alexandre E, Lefranc JP, Lhuillier P, Uzan S, Jannet D, Uzan M, Antoine M, Huart J, Ganansia V, Milliez J, Blondon J, Housset M, Schlienger M. Int J Radiat Oncol Biol Phys. 2001 May; 50(1):81-97.

Modeling the hepatitis C virus epidemic in France. Deuffic S, Buffat L, Poynard T, Valleron AJ. Hepatology. 1999 May; 29(5):1596-601.

Locoregional recurrence of adenocarcinomas of the rectum treated with irradiation combined with or without excision surgery. Touboul E, Buffat L, Minne JF, Ganansia V, Mitry E, Balosso J, Breteau N, Gallot D, Parc R, Schlienger M, Laugier A, Housset M. Cancer Radiother. 1999 Jan-Feb; 3(1):39-50.

Local recurrences and distant metastases after breast-conserving surgery and radiation therapy for early breast cancer. Touboul E, Buffat L, Belkacémi Y, Lefranc JP, Uzan S, Lhuillier P, Faivre C, Huart J, Lotz JP, Antoine M, Pène F, Blondon J, Izrael V, Laugier A, Schlienger M, Housset M. Int J Radiat Oncol Biol Phys. 1999 Jan; 43(1):25-38.

A strategy for finding regions of similarity in complete genome sequences. Vincens P, Buffat L, André C, Chevrolat JP, Boisvieux JF, Hazout2 S. Bioinformatics. 1998; 14(8):715-25.

Single-fraction stereotactic radiotherapy: a dose-response analysis of arteriovenous malformation obliteration. Touboul E, Al Halabi A, Buffat L, Merienne L, Huart J, Schlienger M, Lefkopoulos D, Mammar H, Missir O, Meder JF, Laurent A, Housset M. Int J Radiat Oncol Biol Phys. 1998 Jul; 41(4):855-61.

Trends in primary liver cancer. Deuffic S, Poynard T, Buffat L, Valleron AJ. Lancet. 1998 Jan; 351(9097):214-5.

Primary chemotherapy and preoperative irradiation for patients with stage II larger than 3 cm or locally advanced non-inflammatory breast cancer. Touboul E, Lefranc JP, Blondon J, Buffat L, Deniaud E, Belkacémi Y, Benmiloud M, Huart J, Laugier A, Schlienger M. Radiother Oncol. 1997 Mar; 42(3):219-29.

Assessment of genetic diversity in space by superimposition of a distorted geographic map with a spatial population clustering. Application to GM haplotypes of native Amerindian tribes. Mourrieras B, Dugoujon JM, Buffat L, Hazout S. Ann Hum Genet. 1997 Jan; 61(Pt 1):37-47.

Possibility of conservative local treatment after combined chemotherapy and preoperative irradiation for locally advanced noninflammatory breast cancer. Touboul E, Buffat L, Lefranc JP, Blondon J, Deniaud E, Mammar H, Laugier A, Schlienger M. Int J Radiat Oncol Biol Phys. 1996 Mar; 34(5):1019-28.

Epidermoid carcinoma of the anal margin: 17 cases treated with curative-intent radiation therapy. Touboul E, Schlienger M, Buffat L, Lefkopoulos D, Yao XG, Parc R, Tiret E, Gallot D, Malafosse M, Laugier A. Radiother Oncol. 1995 Mar; 34(3):195-202.

Conservative versus nonconservative treatment of epidermoid carcinoma of the anal canal for tumors longer than or equal to 5 centimeters. A retrospective comparison. Touboul E, Schlienger M, Buffat L, Ozsahin M, Belkacemi Y, Pene F, Balosso J, Lefkopoulos D, Parc R, Tiret E, et al. Cancer. 1995 Feb; 75(3):786-93.

Early breast cancer: influence of type of boost (electrons vs iridium-192 implant) on local control and cosmesis after conservative surgery and radiation therapy. Touboul E, Belkacemi Y, Lefranc JP, Uzan S, Ozsahin M, Korbas D, Buffat L, Balosso J, Pene F, Blondon J, et al. Radiother Oncol. 1995 Feb; 34(2):105-13.

Radiation therapy with or without surgery in the management of low-grade brain astrocytomas. A retrospective study of 120 patients. Touboul E, Schlienger M, Buffat L, Balosso J, Minne JF, Schwartz LH, Pene F, Masri-Zada T, Lot G, Devaux B. Bull Cancer Radiother. 1995; 82(4):388-95.

"Iso-depth contour map" of a molecular surface. Badel-Chagnon A, Nessi J, Buffat L, Hazout S. J Mol Graph. 1994 Sep; 12(3):162-8, 193.

Kidney mobility during respiration. Schwartz LH, Richaud J, Buffat L, Touboul E, Schlienger M. Radiother Oncol. 1994 Jul; 32(1):84-6.

Epidermoid carcinoma of the anal canal. Results of curative-intent radiation therapy in a series of 270 patients. Touboul E, Schlienger M, Buffat L, Lefkopoulos D, Pène F, Parc R, Tiret E, Gallot D, Malafosse M, Laugier A. Cancer. 1994 Mar; 73(6):1569-79.

Automatic search for model to simulate the differentiation of T lymphocytes within the thymus. Buffat L, Mary JY. Acta Biotheor. 1992 Sep; 40(2-3):205-20.

Revisiting statistical methods to assess the effect of hematopoietic inhibitors using colony-forming assays. Mulletin J, Buffat L, Bonnet D, Guigon M, Mary JY. Ann N Y Acad Sci. 1991; 628:420-32.