@article{pmid25209580,

title = {Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib},

author = {Ahmed Idbaih and Karima Mokhtari and Jean-François Emile and Damien Galanaud and Hayat Belaid and Simon de Bernard and Neila Benameur and Vlad-Ciprian Barlog and Dimitri Psimaras and Jean Donadieu and Catherine Carpentier and Nadine Martin-Duverneuil and Julien Haroche and Loic Feuvret and Noel Zahr and Jean-Yves Delattre and Khê Hoang-Xuan},

doi = {10.1212/WNL.0000000000000880},

issn = {1526-632X},

year  = {2014},

date = {2014-10-01},

urldate = {2014-10-01},

journal = {Neurology},

volume = {83},

number = {16},

pages = {1478--1480},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Idbaih2014-pa,

title = {Dramatic response of a BRAF V600E-mutated primary CNS  histiocytic sarcoma to vemurafenib},

author = {Ahmed Idbaih and Karima Mokhtari and Jean-Franc cois Emile and Damien Galanaud and Hayat Belaid and Simon Bernard and Neila Benameur and Vlad-Ciprian Barlog and Dimitri Psimaras and Jean Donadieu and Catherine Carpentier and Nadine Martin-Duverneuil and Julien Haroche and Loic Feuvret and Noel Zahr and Jean-Yves Delattre and Kh^e Hoang-Xuan},

doi = {10.1212/WNL.0000000000000880},

year  = {2014},

date = {2014-10-01},

urldate = {2014-10-01},

journal = {Neurology},

volume = {83},

number = {16},

pages = {1478--1480},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid24516120,

title = {T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow},

author = {Cécile Daussy and Fabrice Faure and Katia Mayol and Sébastien Viel and Georg Gasteiger and Emily Charrier and Jacques Bienvenu and Thomas Henry and Emilie Debien and Uzma A Hasan and Jacqueline Marvel and Keigyou Yoh and Satoru Takahashi and Immo Prinz and Simon de Bernard and Laurent Buffat and Thierry Walzer},

doi = {10.1084/jem.20131560},

issn = {1540-9538},

year  = {2014},

date = {2014-03-01},

urldate = {2014-03-01},

journal = {J Exp Med},

volume = {211},

number = {3},

pages = {563--577},

abstract = {Trail(+)DX5(-)Eomes(-) natural killer (NK) cells arise in the mouse fetal liver and persist in the adult liver. Their relationships with Trail(-)DX5(+) NK cells remain controversial. We generated a novel Eomes-GFP reporter murine model to address this question. We found that Eomes(-) NK cells are not precursors of classical Eomes(+) NK cells but rather constitute a distinct lineage of innate lymphoid cells. Eomes(-) NK cells are strictly dependent on both T-bet and IL-15, similarly to NKT cells. We observed that, in the liver, expression of T-bet in progenitors represses Eomes expression and the development of Eomes(+) NK cells. Reciprocally, the bone marrow (BM) microenvironment restricts T-bet expression in developing NK cells. Ectopic expression of T-bet forces the development of Eomes(-) NK cells, demonstrating that repression of T-bet is essential for the development of Eomes(+) NK cells. Gene profile analyses show that Eomes(-) NK cells share part of their transcriptional program with NKT cells, including genes involved in liver homing and NK cell receptors. Moreover, Eomes(-) NK cells produce a broad range of cytokines, including IL-2 and TNF in vitro and in vivo, during immune responses against vaccinia virus. Thus, mutually exclusive expression of T-bet and Eomes drives the development of different NK cell lineages with complementary functions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}