@article{Faugaret2014-ap,

title = {Granulomatous response to Coxiella burnetii, the agent of Q  fever: the lessons from gene expression analysis},

author = {Delphine Faugaret and Amira Ben Amara and Julie Alingrin and Aurélie Daumas and Amélie Delaby and Catherine Lépolard and Didier Raoult and Julien Textoris and Jean-Louis M`ege},

doi = {10.3389/fcimb.2014.00172},

year  = {2014},

date = {2014-12-01},

urldate = {2014-12-01},

journal = {Front. Cell. Infect. Microbiol.},

volume = {4},

pages = {172},

publisher = {Frontiers Media SA},

abstract = {The formation of granulomas is associated with the resolution of 

 Q fever, a zoonosis due to Coxiella burnetii; however the 

 molecular mechanisms of granuloma formation remain poorly 

 understood. We generated human granulomas with peripheral blood 

 mononuclear cells (PBMCs) and beads coated with C. burnetii, 

 using BCG extracts as controls. A microarray analysis showed 

 dramatic changes in gene expression in granuloma cells of which 

 more than 50% were commonly modulated genes in response to C. 

 burnetii and BCG. They included M1-related genes and genes 

 related to chemotaxis. The inhibition of the chemokines, CCL2 

 and CCL5, directly interfered with granuloma formation. C. 

 burnetii granulomas also expressed a specific transcriptional 

 profile that was essentially enriched in genes associated with 

 type I interferon response. Our results showed that granuloma 

 formation is associated with a core of transcriptional response 

 based on inflammatory genes. The specific granulomatous response 

 to C. burnetii is characterized by the activation of type 1 

 interferon pathway.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Idbaih2014-pa,

title = {Dramatic response of a BRAF V600E-mutated primary CNS  histiocytic sarcoma to vemurafenib},

author = {Ahmed Idbaih and Karima Mokhtari and Jean-Franc cois Emile and Damien Galanaud and Hayat Belaid and Simon Bernard and Neila Benameur and Vlad-Ciprian Barlog and Dimitri Psimaras and Jean Donadieu and Catherine Carpentier and Nadine Martin-Duverneuil and Julien Haroche and Loic Feuvret and Noel Zahr and Jean-Yves Delattre and Kh^e Hoang-Xuan},

doi = {10.1212/WNL.0000000000000880},

year  = {2014},

date = {2014-10-01},

urldate = {2014-10-01},

journal = {Neurology},

volume = {83},

number = {16},

pages = {1478--1480},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid25209580,

title = {Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib},

author = {Ahmed Idbaih and Karima Mokhtari and Jean-François Emile and Damien Galanaud and Hayat Belaid and Simon de Bernard and Neila Benameur and Vlad-Ciprian Barlog and Dimitri Psimaras and Jean Donadieu and Catherine Carpentier and Nadine Martin-Duverneuil and Julien Haroche and Loic Feuvret and Noel Zahr and Jean-Yves Delattre and Khê Hoang-Xuan},

doi = {10.1212/WNL.0000000000000880},

issn = {1526-632X},

year  = {2014},

date = {2014-10-01},

urldate = {2014-10-01},

journal = {Neurology},

volume = {83},

number = {16},

pages = {1478--1480},

keywords = {},

pubstate = {published},

tppubtype = {article}

}